Clustering and Detection of 5’ Splice Sites of mRNA by k Weight Matrix Model
نویسندگان
چکیده
Biological signals on DNA sequences such as TATA box, GC box, CAAT box, the Shine-Dalgarno sequence in the promoter regions, and splice sites (donor/acceptor sites) in eukaryotic mRNA are of considerable interest because they play numerous crucial roles in binding with proteins, or RNA. Recently it has been suggested that the 5’ splice site recognition is performed in vivo through a combination of several rules which are still unclear [1].
منابع مشابه
Clustering and Detection of 5' Splice Sites of mRNA by k Weight-Matrices Model
We propose a novel method to detect 5' splice sites of eukaryotic mRNA. We have grouped the 5' splice splice sites into various classes. The clustered sites are represented by a set of PWMs. The clustering algorithm is similar to k-means clustering algorithm but the distance definition and the training score function were arranged. The clustered PWMs were applied to 5' splice site detection. Th...
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